Re: [Renaliste]Lithium & Diabète insipide

[JMF]

May be of interest ..
certes c'est chez le rat mais
"
1: Nephrol Dial Transplant. 2005 Jan;20(1):65-70. Epub 2004 Nov 16.
N-Acetylcysteine ameliorates lithium-induced renal failure in rats.
  a.. Efrati S,
  b.. Averbukh M,
  c.. Berman S,
  d.. Feldman L,
  e.. Dishy V,
  f.. Kachko L,
  g.. Weissgarten J,
  h.. Golik A,
  i.. Averbukh Z.
Department of Medicine A, Assaf Harofeh Medical Center, Zerifin, Israel. 
efratishai at 013.net.il

BACKGROUND: Prolonged lithium treatment may induce progressive deterioration 
of renal function in humans and experimental animals. N-Acetylcysteine (NAC) 
has been shown to be effective in the prevention of hypoperfusion and 
toxin-induced renal failure, but its effect on lithium nephrotoxicity has 
not been evaluated yet. The purpose of this study was to examine a possible 
renoprotective effect of NAC against lithium-induced renal failure in a rat 
model. METHODS: Moderate renal failure was induced in 40 Sprague-Dawley rats 
using a 5 week protocol including 3 weeks of lithium chloride administration 
in the drinking water. The animals were divided randomly into two equal 
groups receiving either 10 mg/kg NAC or saline by two daily intraperitoneal 
injections. In week 6, the glomerular filtration rate (GFR) was assessed by 
99mTechnetium diethylene triaminepentaacetic acid, and serum creatinine, 
blood urea nitrogen (BUN) and 24 h urinary protein and osmolarity were 
measured. Kidneys were excised for pathological evaluation. RESULTS: At the 
end of the lithium protocol, the GFR was significantly higher in the 
NAC-treated group compared with the control group, 0.92+/-0.35 vs 
0.56+/-0.25 ml/min/100 g, respectively, P = 0.002. Serum creatinine and BUN 
were also significantly lower in the NAC-treated group 1.009+/-0.107 vs 
1.143+/-0.118 mg/dl, P = 0.001, and 83.9+/-6.8 vs 88.95+/-7.1 mg/dl, P = 
0.28, respectively. The percentages of tubular necrosis and tubular lumen 
obstruction, evaluated by light microscopy, were significantly lower in the 
NAC-treated group, P = 0.002 and P = 0.007, respectively.

CONCLUSIONS: NAC treatment has a renoprotective effect against 
lithium-induced renal failure in a rat model.  "

JM Faivre


----- Original Message ----- 
From: "Dr Jean Claude Glachant" <jcglachant at ch-bourg01.fr>
To: "Liste de disc ussion des né phrologues francophones" 
<renaliste at nephrodial.org>
Sent: Tuesday, January 23, 2007 2:25 PM
Subject: Re: [Renaliste] [Renalist e] Diabète insipide


Message de la liste nephrologique francophone RENALISTE
----------------------------------
est ce efficace ??

j'ai la notion que la polyurie du lithium est liée à un Diabète
insipide néphrogénique.


JC.Glachant

En réponse à Jean-Claude Stolear <Jean-Claude.Stolear at rhms.be>:

> Message de la liste nephrologique francophone RENALISTE
> ----------------------------------



JC.Glachant

Néphrologie-dialyse
0474454271
mail perso : glachant at free.fr
mail hôpital : jcglachant at ch-bourg01.fr

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