<html><head><meta http-equiv="Content-Type" content="text/html charset=utf-8"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space;" class="">Cher Collègue,<div class="">Un lien CDT - et dialyse existe (cf ref plus bas, en HD)</div><div class="">Cordialement,</div><div class=""><br class=""></div><div class="">François Vrtovsnik</div><div class="">Service de Néphrologie</div><div class="">Hôpital Bichat, APHP</div><div class=""><br class=""></div><div class="">
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<!--StartFragment--><p class="MsoNormal"><b class=""><span style="font-size:11.0pt;font-family:Calibri;mso-ascii-theme-font:major-latin;
mso-hansi-theme-font:major-latin" class="">Clin Biochem. 2010 Sep;43(13-14):1148-51. False
positive carbohydrate-deficient transferrin results in chronic hemodialysis
patients related to the analytical methodology. </span></b><span style="font-family: Calibri; font-size: 11pt;" class="">Wolff F,
Mesquita M, Corazza F, Demulder A, Willems D.</span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri;
mso-ascii-theme-font:major-latin;mso-hansi-theme-font:major-latin" class="">Chronic
kidney disease stage V is associated with a metabolic acidosis, a disturbance
also observed in heavy alcohol consumption. Carbohydrate-deficient transferrin
is considered the most accurate biomarker for identifying chronic alcohol
abuse. We tested whether increased CDT results occurred in patients on dialysis
therapy. </span><span style="font-family: Calibri; font-size: 11pt;" class="">One hundred
twenty-two samples from HD patients were analyzed by three different analytical
methods and the results were compared with those obtained in 48 healthy
volunteers. </span><span style="font-family: Calibri; font-size: 11pt;" class="">On the basis
of the upper 97.5th percentile, positive CDT results were found in 25.4%, 9.8%
and 12.3% of the HD patients with particle-enhanced immunonephelometry,
capillary electrophoresis and HPLC, respectively. A significant correlation
between CDT values and transferrin concentration was found for the
particle-enhanced immunonephelometric test (r: -0.311; p: 0.0009). </span><span style="font-family: Calibri; font-size: 11pt;" class="">CONCLUSIONS:
A high rate of positive CDT results was observed in HD patients with the
particle-enhanced immunonephelometry and seems to be related to the low
transferrin concentration.</span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri;
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<!--EndFragment--><div><blockquote type="cite" class=""><div class="">Le 7 avr. 2016 à 10:21, Alrifai Mohamed Assem <<a href="mailto:mohamed-assem.alrifai@chi-eureseine.fr" class="">mohamed-assem.alrifai@chi-eureseine.fr</a>> a écrit :</div><br class="Apple-interchange-newline"><div class=""><o:smarttagtype namespaceuri="urn:schemas-microsoft-com:office:smarttags" name="PersonName" style="font-family: Helvetica; font-size: 12px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-stroke-width: 0px;" class=""><div class="Section1" style="page: Section1;"><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman';" class=""><font size="2" face="Arial" class=""><span style="font-size: 10pt; font-family: Arial;" class="">Cher collègues<o:p class=""></o:p></span></font></div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman';" class=""><font size="2" face="Arial" class=""><span style="font-size: 10pt; font-family: Arial;" class=""><o:p class=""> </o:p></span></font></div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman';" class=""><font size="2" face="Arial" class=""><span style="font-size: 10pt; font-family: Arial;" class="">Je me permet de vous écrire afin d’avoir votre avis concernant un de mes patients de DP qui présente un taux de CDT( carboxy déficient transferrine) élevé à 2.2 ( résultat pathologique si > à 1.6 ) raison pour la quelle son permis de conduire a été plusieurs fois suspendu par le médecin de la préfecture.</span></font><o:p class=""></o:p></div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman';" class=""><font size="2" face="Arial" class=""><span style="font-size: 10pt; font-family: Arial;" class="">L’avis d’addictologue consiste, après une enquête bien détaillée, en un problème d’utilisation de liquide hydro alcoolique ou certain produits hygiènes ! Mais la préfecture récuse ce raisonnement !<o:p class=""></o:p></span></font><o:p class=""></o:p></div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman';" class=""><font size="2" face="Arial" class=""><span style="font-size: 10pt; font-family: Arial;" class=""><o:p class=""> </o:p></span></font><o:p class=""></o:p></div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman';" class=""><font size="2" face="Arial" class=""><span style="font-size: 10pt; font-family: Arial;" class="">Le patient est sous 4 échanges par jour de 2 Iso et 2 Extra . je n’ai pas trouvé dans les littérature une recherche faite à ce sujet !<o:p class=""></o:p></span></font></div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman';" class=""><font size="2" face="Arial" class=""><span style="font-size: 10pt; font-family: Arial;" class=""> </span></font><o:p class=""></o:p></div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman';" class=""><font size="2" face="Arial" class=""><span style="font-size: 10pt; font-family: Arial;" class="">Avez vous rencontré un cas pareil ? Peut-il avoir en lien avec<span class="apple-converted-space"> <st1:personname class="" u1:st="on" productid="la DP"></st1:personname></span><st1:personname productid="la DP" w:st="on" class="">la DP</st1:personname> ?<span class="Apple-converted-space"> </span><o:p class=""></o:p></span></font></div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman';" class=""><font size="2" face="Arial" class=""><span style="font-size: 10pt; font-family: Arial;" class=""><o:p class=""> </o:p></span></font></div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman';" class=""><font size="2" face="Arial" class=""><span style="font-size: 10pt; font-family: Arial;" class="">Cordialement</span></font><o:p class=""></o:p></div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman';" class=""><font size="2" face="Arial" class=""><span style="font-size: 10pt; font-family: Arial;" class=""><o:p class=""> </o:p></span></font></div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman';" class=""><font size="2" face="Arial" class=""><span style="font-size: 10pt; font-family: Arial;" class=""><o:p class=""> </o:p></span></font></div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman';" class=""><font size="2" face="Arial" class=""><span style="font-size: 10pt; font-family: Arial;" class="">Docteur Assem ALRIFAI</span></font><o:p class=""></o:p></div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman';" class=""><font size="2" face="Arial" class=""><span style="font-size: 10pt; font-family: Arial;" class="">Praticien Hosptalier Contractuel</span></font><o:p class=""></o:p></div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman';" class=""><font size="2" face="Arial" class=""><span style="font-size: 10pt; font-family: Arial;" class="">Service de Néphrologie/Hémodialyse</span></font><o:p class=""></o:p></div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman';" class=""><font size="2" face="Arial" class=""><span style="font-size: 10pt; font-family: Arial;" class="">CH Eure Seine</span></font><o:p class=""></o:p></div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman';" class=""><font size="2" face="Arial" class=""><span style="font-size: 10pt; font-family: Arial;" class="">Tel : 02.32.33.85.33</span></font><o:p class=""></o:p></div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman';" class=""><font size="3" face="Times New Roman" class=""><span style="font-size: 12pt;" class=""><o:p class=""> </o:p></span></font></div></div>_______________________________________________<br class="">Renaliste mailing list<br class=""><a href="mailto:Renaliste@nephrodial.org" style="color: purple; text-decoration: underline;" class="">Renaliste@nephrodial.org</a><br class=""><a href="http://nephrodial.org/cgi-bin/mailman/listinfo/renaliste" style="color: purple; text-decoration: underline;" class="">http://nephrodial.org/cgi-bin/mailman/listinfo/renaliste</a></o:smarttagtype></div></blockquote></div><br class=""></div></body></html>